New & Noteworthy

Disease Pages at SGD: Linking Yeast Genetics and Human Disease

December 22, 2018

SGD’s Disease Ontology page for neurodegenerative disease

To promote the use of yeast as a catalyst for biomedical research, SGD utilizes the Disease Ontology (DO) to describe human diseases that are associated with yeast homologs. Disease Ontology annotations to yeast genes are now available through SGD’s new Disease pages. Each page corresponds to a Disease Ontology term, such as amyotrophic lateral sclerosis, and lists out all yeast genes annotated to the term by SGD.

Yeast genes with one or more human disease associations will also have a new Disease Summary tab (example: MIP1), accessible from the genes’ respective locus pages. The Disease summary tab shows all manually curated, high-throughput, and computational disease annotations for the yeast gene. Additionally, these pages feature a network diagram that depicts shared disease annotations for other yeast genes and their human homologs.

The shared disease annotations diagram for MIP1

For more information, check out SGD’s Disease Ontology help page. Explore the new Disease pages and features, and be sure to let us know if you have any feedback or questions.

Categories: New Data