Complex: SWI/SNF chromatin remodelling complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1150
- Systematic Name
- ARP7:ARP9:RTT102:SNF2:SNF5:SNF6:SNF11:SNF12:SWI1:SWI3:SWP82:TAF14
- SGD ID
- SGD:S000217596
- Aliases
- SWI/SNF ATP-dependent chromatin remodelling complex ; SWI/SNF ATP-dependent nucleosome-remodeling complex ; SWItch/Sucrose Non-Fermentable complex
- Description
- An ATP-dependent chromatin remodelling complex which disrupts the nucleosome structure, increases the binding of transcription factors to nucleosomes, mobilizes histone octamers along DNA in cis, transfers histone octamers to different DNA fragments, displaces histone H2A/H2B dimers and generates superhelical torsion in DNA. Binds preferentially to four-way DNA and promotes resection initiation at a DNA double-strand break. Binds to DNA and nucleosomes without any DNA sequence specificity.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables ATP hydrolysis activity (IDA)
- enables ATP-dependent chromatin remodeler activity (IDA)
- enables double-stranded DNA binding (IDA)
- Biological Process
-
- involved in chromatin remodeling (IDA)
- involved in positive regulation of double-strand break repair via homologous recombination (BSR)
- involved in regulation of transcription by RNA polymerase II (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Zhang Z, et al. (2018) Architecture of SWI/SNF chromatin remodeling complex. Protein Cell 9(12):1045-1049 PMID: 29546678
- Dutta A, et al. (2017) Composition and Function of Mutant Swi/Snf Complexes. Cell Rep 18(9):2124-2134 PMID: 28249159
- Venkataramanan S, et al. (2017) The chromatin remodeling complex Swi/Snf regulates splicing of meiotic transcripts in Saccharomyces cerevisiae. Nucleic Acids Res 45(13):7708-7721 PMID: 28637241
Resources
IntAct | ModelArchive | PDB:3WEE | PDB:4I6M ... Show all Show fewer