Complex: Fatty-acyl-CoA synthase
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1162
- Systematic Name
- 6xFAS1:6xFAS2
- SGD ID
- SGD:S000217935
- Aliases
- FAS ; Fatty acid synthase complex ; acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing) ; holo-[acyl-carrier-protein] synthase complex
- Description
- Catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. Consists of a multifunctional enzyme composed of two non-identical alpha and beta subunits which are organized in an alpha6beta6 complex with 6 sites of fatty acid synthesis. The alpha subunit, FAS2, contains domains for acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. The beta subunit, FAS 1, contains domains for [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 2PFF | 2UV8 | 2VKZ | 3HMJ | 6JSH | 6JSI | 6QL6 | 6QL9 | 6TA1 | 6WC7 | 8PRV | 8PRW | 8PS1 | 8PS2 | 8PS8 | 8PS9 | 8PSA | 8PSF | 8PSG | 8PSJ | 8PSK | 8PSL | 8PSM | 8PSP |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables fatty-acyl-CoA synthase activity (IDA)
- enables phosphopantetheine binding (IDA)
- Biological Process
-
- involved in long-chain fatty acid biosynthetic process (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
No shared annotations
References
List of references used specifically to curate the information on this page.
- Tehlivets O, et al. (2007) Fatty acid synthesis and elongation in yeast. Biochim Biophys Acta 1771(3):255-70 PMID: 16950653
- Stoops JK, et al. (1992) Structure-function relationships of the yeast fatty acid synthase: negative-stain, cryo-electron microscopy, and image analysis studies of the end views of the structure. Proc Natl Acad Sci U S A 89(14):6585-9 PMID: 1631160
External Identifiers
EMDB: EMD-10420 | EMDB: EMD-17839 | EMDB: EMD-17840 | EMDB: EMD-17842 | EMDB: EMD-17843 | EMDB: EMD-17846 | EMDB: EMD-17847 | EMDB: EMD-17848 | EMDB: EMD-17851 | EMDB: EMD-17852 | EMDB: EMD-17853 | EMDB: EMD-17854 | EMDB: EMD-17855 | EMDB: EMD-17856 | EMDB: EMD-17859 | EMDB: EMD-21602 | EMDB: EMD-4578 | EMDB: EMD-9881 | EMDB: EMD-9882 | IntEnz: 1.1.1.100 | IntEnz: 1.3.1.9 | IntEnz: 2.3.1.38 | IntEnz: 2.3.1.39 | IntEnz: 2.3.1.41 | IntEnz: 2.3.1.86 | IntEnz: 3.1.2.14 | IntEnz: 4.2.1.59
Resources
IntAct | ModelArchive | PDB:2PFF | PDB:2UV8 | PDB:2VKZ | PDB:3HMJ | PDB:6JSH | PDB:6JSI | PDB:6QL6 | PDB:6QL9 | PDB:6TA1 ... Show all | PDB:6WC7 | PDB:8PRV | PDB:8PRW | PDB:8PS1 | PDB:8PS2 | PDB:8PS8 | PDB:8PS9 | PDB:8PSA | PDB:8PSF | PDB:8PSG | PDB:8PSJ | PDB:8PSK | PDB:8PSL | PDB:8PSM | PDB:8PSP Show fewer