Complex: Gamma tubulin small complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1198
- Systematic Name
- SPC97:SPC98:2XTUB4
- SGD ID
- SGD:S000217618
- Aliases
- TUB4 complex ; gamma-TUSC ; gamma-TuRC ; gamma-tubulin ring complex
- Description
- Seeds microtubule nucleation at microtubule-organizing centres, controlling the location and timing of nucleation. Component of the spindle pole body, which is responsible for the nucleation and organisation of microtubules within the cell, thus playing a role in chromosome segregation in mitosis and meiosis and controlling cytoplasmic interphase microtubules. The complex is bound directly to the spindle pole body by SPC110 (P32380) on the nuclear face and SPC72 (P39723) on the cytoplasmic face.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 7M2Z |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables structural constituent of cytoskeleton (BSR)
- Biological Process
-
- involved in regulation of microtubule nucleation (BSR)
- Cellular Component
-
- located in spindle pole body (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Brilot AF, et al. (2021) CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation. Elife 10 PMID: 33949948
- Greenberg CH, et al. (2016) Structure of γ-tubulin small complex based on a cryo-EM map, chemical cross-links, and a remotely related structure. J Struct Biol 194(3):303-10 PMID: 26968363
Resources
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