Complex: DOM34-HBS1 ribosome dissociation complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-465
- Systematic Name
- DOM34:HBS1
- SGD ID
- SGD:S000217632
- Description
- Mediates dissociation of inactive 80S ribosomes associated in a non-translating, inactive pool, for example following stress-induced global shut-down of translation. Binds to the ribosomal A site. GTP hydrolysis, dissociation of HBS1 and accommodation of DOM34 in the ribosome, results in the binding of RLI1 (Q03195) followed by ATP-dependent subunit dissociation. Also plays a role in RNA quality control in No-Go decay, releasing ribosomes that are stalled at the 3-prime end of mRNAs lacking a termination codon.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 3IZQ |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables GTPase activity (IDA)
- enables ribosome binding (IDA)
- Biological Process
-
- involved in nuclear-transcribed mRNA catabolic process, no-go decay (IDA)
- involved in positive regulation of translational initiation (IDA)
- involved in rescue of stalled ribosome (IDA)
- involved in ribosome disassembly (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- van den Elzen AM, et al. (2014) Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress. EMBO J 33(3):265-76 PMID: 24424461
- Becker T, et al. (2011) Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome. Nat Struct Mol Biol 18(6):715-20 PMID: 21623367
- Shoemaker CJ, et al. (2010) Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay. Science 330(6002):369-72 PMID: 20947765
- Carr-Schmid A, et al. (2002) Novel G-protein complex whose requirement is linked to the translational status of the cell. Mol Cell Biol 22(8):2564-74 PMID: 11909951
Resources
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