Gene Ontology Help

SUM1-RFM1-HST1 histone deacetylase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Histone deacetylase complex which represses the expression of middle sporulation genes during vegetative growth. The histone H3 specific methyltransferase SET1 (P38827) promotes association of the locus-specific SUM1-RFM1-HST1 repressor complex with the middle sporulation element in the promoter region of a subset of genes. Once bound, the complex maintains histone H4 lys-5 in a deacetylated state. The complex is also required for full initiation capacity of ORC-mediated replication initiation at consensus sequence within origins of replication in the genome.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

molecular function, regulation of DNA metabolic process