Gene Ontology Help

ECM11-GMC2 synaptonemal assembly activation factor complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Facilitates the assembly of the transverse filament of the synaptonemal complex (CPX-1387) by promoting the oligomerisation of ZIP1 (P31111). Recruited to the site of synapsis initiation complex (CPX-1386) binding where it may act to stabilise the nascent ZIP1 oligomer. ECM11 SUMOylation promotes ZIP1 assembly whilst ZIP1 promotes ECM11 SUMOylation in a positive feedback loop leading to further assembly of ZIP1, loading of ECM11-GMC2 and SUMOylation of ECM11 until the Synaptonemal complex is fully established.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

cellular component assembly, chromosome organization, chromosome, nuclear chromosome, organelle, intracellular membraneless organelle