Gene Ontology Help

Nucleotide excision repair factor 2 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Nucleotide excision repair damage-recognition heterodimer. Binds damaged DNA and recruits the NEF1 and NEF3 complexes. Rad4 inserts a beta-hairpin through the DNA duplex, causing the two damaged base pairs to flip out of the double helix. Lesion recognition does not appear to be based in structural discrimination between normal and damaged DNA by Rad4/XPC, but may be due to a ‘kinetic gating’ mechanism, whereby the DNA lesion selectivity arises mainly from the kinetic competition between Rad4-induced DNA opening and the residence time of Rad4 at a given site.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, chromosome organization