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BRE1-RAD6 ubiquitin ligase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Ubiquitin ligase complex. Mono-ubiquitinates the histone H2B residue lysine-123. This provides a specific tag for epigenetic transcriptional activation in addition to modulating the formation of double-strand breaks during meiosis and being a prerequisite for DNA-damage checkpoint activation. Ubiquitination of lys-123 is a prerequisite for the subsequent di- and trimethylation of histone H3 on K4 and K79 which is important for telomeric gene silencing. A BRE1-associated protein, LGE1, is also required for H2B monoubiquitination and may be part of a larger complex.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

acyltransferase activity, transferase activity, DNA damage response, DNA metabolic process, DNA recombination, DNA repair, chromatin organization, chromosome organization, histone modification, protein modification by small protein conjugation or removal, response to stress, telomere organization

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.