Primary Literature
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- Li H, et al. (2024) Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation. Mol Cell 84(7):1290-1303.e7 PMID: 38401542
- Lee HG, et al. (2023) SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex. Proc Natl Acad Sci U S A 120(1):e2213703120 PMID: 36574706
- Oppenheim T, et al. (2023) The Cdc48 N-terminal domain has a molecular switch that mediates the Npl4-Ufd1-Cdc48 complex formation. Structure 31(7):764-779.e8 PMID: 37311459
- Ohkuni K, et al. (2022) Cdc48Ufd1/Npl4 segregase removes mislocalized centromeric histone H3 variant CENP-A from non-centromeric chromatin. Nucleic Acids Res 50(6):3276-3291 PMID: 35234920
- Deegan TD, et al. (2020) CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold. Elife 9 PMID: 32804080
- Higgins R, et al. (2020) The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis. Cell Rep 32(2):107898 PMID: 32668237
- Sato Y, et al. (2019) Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4. Nat Commun 10(1):5708 PMID: 31836717
- Twomey EC, et al. (2019) Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science 365(6452) PMID: 31249135
- Parisi E, et al. (2018) Cdc48/p97 segregase is modulated by cyclin-dependent kinase to determine cyclin fate during G1 progression. EMBO J 37(16) PMID: 29950310
- Finley D, et al. (2012) The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics 192(2):319-60 PMID: 23028185
- Barbin L, et al. (2010) The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase. Biochem Biophys Res Commun 394(2):335-41 PMID: 20206597
- Shcherbik N and Haines DS (2007) Cdc48p(Npl4p/Ufd1p) binds and segregates membrane-anchored/tethered complexes via a polyubiquitin signal present on the anchors. Mol Cell 25(3):385-97 PMID: 17289586
- Gauss R, et al. (2006) The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment. EMBO J 25(9):1827-35 PMID: 16619026
- Park S, et al. (2005) Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites. Structure 13(7):995-1005 PMID: 16004872
- Bays NW, et al. (2001) HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Mol Biol Cell 12(12):4114-28 PMID: 11739805
- Hitchcock AL, et al. (2001) The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol Biol Cell 12(10):3226-41 PMID: 11598205
- Rape M, et al. (2001) Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell 107(5):667-77 PMID: 11733065