HMC complex

Primary Literature

Lan C, et al. (2004) A novel mode of chaperone action: heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex. J Biol Chem 279(26):27607-12 PMID: 15102838
Hon T, et al. (2001) The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme. Mol Cell Biol 21(23):7923-32 PMID: 11689685
Zhang L, et al. (1998) Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1. Mol Cell Biol 18(7):3819-28 PMID: 9632766
Zhang L, et al. (1993) Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1. Proc Natl Acad Sci U S A 90(7):2851-5 PMID: 8464899

Additional Literature

Girstmair H, et al. (2019) The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range. Nat Commun 10(1):3626 PMID: 31399574

Truman AW, et al. (2015) The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage. Data Brief 2:12-5 PMID: 26217697

O'Connell JD, et al. (2014) A proteomic survey of widespread protein aggregation in yeast. Mol Biosyst 10(4):851-861 PMID: 24488121

Krukenberg KA, et al. (2009) Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide. Protein Sci 18(9):1815-27 PMID: 19554567

Cunningham CN, et al. (2008) Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90. J Biol Chem 283(30):21170-8 PMID: 18492664

Hickman MJ and Winston F (2007) Heme levels switch the function of Hap1 of Saccharomyces cerevisiae between transcriptional activator and transcriptional repressor. Mol Cell Biol 27(21):7414-24 PMID: 17785431

Lee HC, et al. (2003) Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1. Mol Cell Biol 23(16):5857-66 PMID: 12897155

Liu XD, et al. (1999) The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone. J Biol Chem 274(38):26654-60 PMID: 10480867

Sobel SG and Wolin SL (1999) Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Mol Biol Cell 10(11):3849-62 PMID: 10564276

Näit-Kaoudjt R, et al. (1997) Some DNA targets of the yeast CYP1 transcriptional activator are functionally asymmetric--evidence of two half-sites with different affinities. Eur J Biochem 244(2):301-9 PMID: 9118994

Pfeifer K, et al. (1987) Yeast HAP1 activator binds to two upstream activation sites of different sequence. Cell 49(1):19-27 PMID: 3030565

Prezant T, et al. (1987) Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation. Mol Cell Biol 7(9):3252-9 PMID: 2823123

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HMC complex Literature

Primary Literature

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