Gene Ontology Help

OPY2-MSB2 osmosensory complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Osmosensor that activates the HOG1 mitogen-activated protein kinase (P32485), which regulates diverse osmoadaptive responses. Increased external osmolarity induces conformational changes in the complex formed between the Hkr1-Msb2 homology (HMH) domain of MSB2 and the cysteine-rich region of OPY2. This conformational change is transmitted across the plasma membrane to induce an interaction between the associated STE20 (Q03497) and STE11 (P23561) protein kinases, thus activating a signal cascade which culminates in HOG1 activation.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

molecular function, response to chemical, response to osmotic stress, response to stress, signal transduction, membrane, plasma membrane