Gene Ontology Help

ATR-ATRIP DNA damage-sensing kinase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Master regulator of the DNA damage response controlling a signaling cascade required for the maintenance of genomic integrity. Activated by RPA complex (CPX-21)-coated single-stranded DNA at the site of DNA double-strand breaks and stalled replication forks. Appears to control the production of an adequate and balanced pool of deoxyribonucleotides and maintain replication fork stability.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

kinase activity, transferase activity, regulation of DNA metabolic process, nucleus, organelle