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DBF20-MOB1 kinase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Probable role in exit from mitosis during the cell cycle. By parology to DBF2-MOB1 kinase complex (CPX-1683), the complex once activated, translocates to the nucleus where it phosphorylates an unknown protein to dislodge CDC14 (Q00684) from NET1 (P47035), resulting in diffusion of CDC14 throughout the nucleus. Phosphorylates CDC14 on several sites that flank the C-terminal nuclear localization signal (NLS) sequences, thereby inhibiting the NLS. Because of this, phosphorylated CDC14 molecules that escape to the cytoplasm cannot efficiently return to the nucleus and dephosphorylate substrates such as CDH1 (P53197) and SWI5 (P08153). Phosphorylates chitin synthase CHS2 (P14180) to regulate cytokinesis.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

kinase activity, transferase activity, protein phosphorylation, regulation of cell cycle

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.