BIK1 / YCL029C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant has both a decreased growth rate and competitive fitness and is both heat and cold sensitive; diploid null mutant displays a reduced number and length of cytoplasmic microtubules, short and broken anaphase spindles, and abnormally positioned nuclei resulting in anucleate and multinucleate cells; null mutant has a strong bilateral karyogamy defect; null mutant has an elevated rate of chromosome loss, is benomyl sensitive and displays an increased fraction of cells with nuclear extensions at the nuclear envelope; overexpression results in chromosomal instability, and a large-budded cell cycle arrest where cells contain a single nucleus located in or near the neck and abnormal cytoplasmic microtubules; heterozygous null mutant is haploproficient

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources