YVH1 / YIR026C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutants grow slowly, have small cell size, decreased competitive fitness, increased replicative lifespan, and exhibit defects in rRNA processing, glycogen accumulation, endocytosis, and protein localization; null mutatns are also sensitive to cold, acetolactate synthase inhibitor sulfometuron methyl, antioxidant spermine, antimicrobial hygromycin B, and radical scavenger dimethyl sulfoxide; homozygous diploid null mutants are resistant to zymocin and to zinc deficiency, but sensitive to TOR inhibitor rapamycin, reducing agent 1,4-dithiothreitol, antimicrobial doxorubicin, and carcinogen benzo[a]pyrene; homozygous diploid nulls are also impaired in cell cycle progression, meiosis, sporulation, and fermentative growth, but have increased lifespan; overexpression slows growth

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources