ELM1 / YKL048C Overview
- Standard Name
- ELM1 1
- Systematic Name
- YKL048C
- SGD ID
- SGD:S000001531
- Aliases
- LDB9 15
- Feature Type
- ORF , Verified
- Description
- Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative metabolism by phosphorylating the activation loop of Kin4p, Hsl1p and Snf1p respectively; cooperates with Hsl7p in recruiting Hsl1p to the septin ring, a prerequisite for subsequent recruitment, phosphorylation, and degradation of Swe1p; forms part of the bud neck ring; regulates cytokinesis 2 3 4 5 6 7 8 9 10 11 12
- Name Description
- ELongated Morphology 1
- Comparative Info
-
Sequence
The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.
Analyze Sequence
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi
S288C vs. other strains
Protein
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.
- Length (a.a.)
- 640
- Mol. Weight (Da)
- 72155.8
- Isoelectric Point
- 8.2
- Median Abundance (molecules/cell)
- 931 +/- 685
- Half-life (hr)
- 6.8
Alleles
Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.
View all ELM1 alleles in SGD search
Gene Ontology
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.
- Summary
- Serine/threonine kinase; involved in cytokinesis, septin ring assembly, cell morphogenesis and bud growth; localizes to the bud neck
View computational annotations
Molecular Function
- Manually Curated
- enables protein kinase activity (HDA)
- enables protein serine/threonine kinase activity (IDA)
Biological Process
- Manually Curated
- involved in budding cell bud growth (IMP)
- involved in cell morphogenesis (IMP)
- involved in cellular response to glucose starvation (IMP)
- acts upstream of or within maltose metabolic process (IMP)
- involved in mitotic cytokinesis (IMP)
- involved in protein localization to septin ring (IMP)
- involved in pseudohyphal growth (IMP)
- involved in septin ring assembly (IMP)
Cellular Component
- Manually Curated
- located in cellular bud neck (HDA)
- located in cellular bud neck septin ring (IDA, IMP)
Phenotype
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.
Classical Genetics
- overexpression
- null
- alkaline pH resistance: decreased
- cell cycle progression through the G2/M phase transition: delayed
- cell shape: abnormal
- cell shape: normal
- chemical compound accumulation: increased
- heat sensitivity: increased
- invasive growth: increased
- protein/peptide distribution: abnormal
- protein/peptide modification: decreased
- pseudohyphal growth: increased
- resistance to chemicals: decreased
- null
- auxotrophy
- bud morphology: abnormal
- budding index: increased
- chemical compound accumulation: abnormal
- chemical compound accumulation: decreased
- chemical compound accumulation: increased
- competitive fitness: decreased
- competitive fitness: increased
- fermentative growth: decreased rate
- haploinsufficient
- heat sensitivity: increased
- innate thermotolerance: increased
- killer toxin resistance: increased
- mutation frequency: increased
- protein/peptide accumulation: increased
- resistance to chemicals: decreased
- resistance to chemicals: increased
- respiratory growth: increased rate
- sporulation efficiency: increased
- stress resistance: decreased
- toxin resistance: decreased
- utilization of carbon source: decreased rate
- UV resistance: decreased
- vegetative growth: decreased rate
- viable
Large-scale Survey
Interaction
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.
1337 total interactions for 810 unique genes
Physical Interactions
- Affinity Capture-MS: 9
- Affinity Capture-RNA: 7
- Affinity Capture-Western: 2
- Biochemical Activity: 17
- Co-localization: 2
- PCA: 2
- Reconstituted Complex: 12
- Two-hybrid: 2
Genetic Interactions
- Dosage Growth Defect: 90
- Dosage Lethality: 2
- Dosage Rescue: 4
- Negative Genetic: 945
- Phenotypic Enhancement: 17
- Phenotypic Suppression: 19
- Positive Genetic: 100
- Synthetic Growth Defect: 60
- Synthetic Lethality: 35
- Synthetic Rescue: 12
Regulation
The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.
Expression
Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.
Summary Paragraph
A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.
Last Updated: 2004-04-15
Literature
All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.