RAD9 / YDR217C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant is sensitive to DNA damaging agents, DNA synthesis and topoisomerase inhibitors; null mutant is sensitive to X-rays, gamma rays and UV radiation; null mutant displays increased chromosome instability including gross chromosomal rearrangements, but decreased reversion rate in the presence of high doses of DNA damaging agents; null mutant displays elevated levels of sumoylated Rfa1p, Rfa2p, and Rad52p after DNA damage; null mutant has a decreased duration of S phase and impaired growth on non-fermentative carbon sources, decreased oxidative stress resistance, and decreased chronological lifespan; overexpression results in a decreased rate of vegetative growth

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources