XRS2 / YDR369C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

XRS2/YDR369C is a non-essential gene; null mutants are viable, slow-growing, and have increased budding index, indicating a higher frequency of budding events, yet competitive fitness is decreased, which may hinder their ability to thrive in resource-limited environments. Null mutants also exhibit decreased resistance to desiccation, making them more vulnerable to dry conditions. The morphology of the endoplasmic reticulum is abnormal, suggesting potential disruptions in protein synthesis and processing. Additionally, the rate of fermentative growth is decreased, indicating impaired metabolic function. Resistance to gamma rays is diminished, heightening sensitivity to radiation, while heat sensitivity is increased, making these mutants more susceptible to elevated temperatures. Metal resistance is also decreased, and mutation frequency is increased, suggesting a higher likelihood of genetic instability. Furthermore, oxidative stress resistance is reduced, which may compromise cellular integrity under stress conditions. Sporulation is decreased, indicating challenges in reproductive success, and telomere length is diminished, which could affect cellular aging and stability. UV resistance is also decreased, further underscoring their vulnerability to environmental stressors. Vacuolar morphology is abnormal, potentially disrupting cellular storage and waste management. Overexpression of XRS2 decreases competitive fitness, indicating that excessive levels of the gene may also be detrimental. However, filamentous growth is increased, suggesting that overexpression may lead to altered growth patterns.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources