SGF73 / YGL066W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant has a shortened chronological lifespan, but has a larger extension of replicative lifespan by caloric restriction than does wild type; null mutation or overexpression cause sensitivity to HU; null mutant displays slow growth on nonfermentable carbon sources; in large-scale studies, null mutant has reduced competitive fitness in several different media and displays chromosome instability, G2 or M phase delay in the mitotic cell cycle, abnormal meiosis, defective endocytosis, and altered transposition rates of different transposable elements; overexpression in the Sigma1278b background confers increased filamentous growth; diploid homozygous null mutant requires myo-inositol, accumulates less glycogen, and is sensitive to desiccation; null mutant displays altered resistance to a variety of chemicals

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources