LSM1 / YJL124C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

LSM1/YJL124C is a non-essential gene; null mutants are viable, slow-growing, and associated with a variety of phenotypes that significantly affect cellular functions and overall fitness. Mutants lacking LSM1 exhibit decreased resistance to acidic pH levels, which may compromise their survival in acidic environments, and an increased rate of apoptosis, indicating heightened programmed cell death. The budding pattern and cell shape are abnormal, suggesting disruptions in normal cellular processes, while cell size is decreased. The chronological lifespan of lsm1 null mutants is also reduced, reflecting a potential trade-off between growth and longevity. Competitive fitness is impaired, leading to decreased viability in resource-limited conditions. Endocytosis is reduced, which may hinder nutrient uptake, and the rate of fermentative growth is diminished, indicating metabolic challenges. Growth during the exponential phase is also decreased, and these mutants exhibit increased sensitivity to heat, making them more vulnerable to elevated temperatures. Resistance to killer toxins is decreased, and nuclear morphology is abnormal, which could impact cellular organization and function. Although oxidative stress resistance is increased, UV resistance is decreased, further underscoring their vulnerability to environmental stressors. Vacuolar morphology is abnormal, potentially disrupting cellular storage and waste management. Overexpression of LSM1 decreases viability.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources