CDC42 / YLR229C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene; conditional mutant arrests as large, unbudded cells and repressible mutant displays a G1 phase cell cycle defect; conditional mutant affects the polarized localization of Sec3p and Sec5p to emerging bud sites, bud tips, and bud necks; mutants with a reduction-of-function allele have a bilateral cell fusion defect; conditional mutant displays increased chromosomal instability; heterozygous diploid shows haploinsufficiency

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources