CNM67 / YNL225C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene in strain S288C, essential in SK1; null mutant has abnormal nuclei and is sensitive to echinocandin B, MMS, bleomycin; null mutant diploid is unable to sporulate; in systematic studies null mutation causes reduced growth rate, poor anaerobic growth, elevated accumulation of polyphosphates and decreased cytosolic protonation; null mutants are also sensitive to oxidative stress and to a variety of chemicals, including rapamycin, quinine, Congo Red, caspofungin; overexpression causes slow growth

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources