TOP1 / YOL006C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant has an increased respiratory but decreased fermentative growth rate; null mutant is resistant to topo I inhibitors but sensitive to topo II inhibitors and DNA damaging agents; null mutant displays decreased resistance to hyperosmotic stress, alkaline pH and metals, but increased resistance to oxidative stress and increased chronological lifespan; homozygous diploid null mutant has increased mitotic chromosome loss, increased loss of heterozygosity and a sporulation defect; overexpression results in a decreased growth rate and enhanced invasive growth

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources