CDC21 / YOR074C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene in strain S288C, non-essential in strain W303; reduction of function decreases competitive fitness, confers sensitivity to nucleobase analog 5-fluorouracil; base-substitution mutants are resistant to cycloheximide, conditionally arrest in meiosis after spindle pole body duplication but before spindle formation for the first meiotic division; heat-sensitive mutants are petite and have an S phase delay at permissive temperature; repression also causes S phase delay; heterozygous diploid nulls are haploinsufficient and subject to chromosome instability

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources