TAF14 / YPL129W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

TAF14/YPL129W is a non-essential gene; null mutants are viable, slow-growing, and associated with a range of phenotypes that significantly influence cellular behavior and overall fitness. Mutants lacking TAF14 exhibit decreased resistance to acidic pH levels, which may compromise their survival in acidic environments. The morphology of the actin cytoskeleton and buds is abnormal, potentially disrupting normal cellular structure and division processes. Additionally, these mutants experience an increased duration of cell cycle progression during the G1 phase, leading to delays in cell division. While cell size is increased, the chronological lifespan of these mutants is decreased, indicating a trade-off between growth and longevity. Competitive fitness is impaired, resulting in decreased viability in resource-limited environments. Endocytosis is also reduced, which may hinder nutrient uptake and cellular function. The growth rate during the exponential phase is diminished, and these mutants show increased sensitivity to heat, making them more vulnerable to elevated temperatures. Resistance to hydrostatic pressure, hyperosmotic stress, and metal exposure is decreased, further highlighting their compromised resilience. Additionally, osmotic stress resistance is reduced, and the ability to withstand enzymatic treatment is diminished. Shmoo formation, a response to mating signals, is abnormal in these mutants, which may affect reproductive success. The subcellular morphology is also altered, and transposable element transposition is decreased, indicating disruptions in genomic stability. Resistance to ultraviolet radiation is reduced, and vacuolar morphology is abnormal, which could impact cellular storage and waste management. Conditional mutants have abnormal bud morphology. When TAF14 is overexpressed, there is an increase in colony sectoring, and abnormal silencing.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources