CDC60 / YPL160W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene; reduction of function increases sensitivity to rapamycin; conditional mutants are subject to chromosome instability at semi-permissive temperature, arrest in G1 as unbudded cells with a single nucleus at elevated temperatures; overexpression slows vegetative growth, enhances pseudohyphal growth; heterozygous diploid nulls are haploinsufficient, sensitive to protein synthesis inhibitor tavaborole

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources