BEM4 / YPL161C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant has a growth defect, decreased competitive fitness, and is both heat and cold sensitive; at elevated temperature null mutant arrests with large, round unbudded cells, some elongated and crooked buds, some multinucleate cells, and an abnormal distribution if actin throughout the cell cortex; haploid and homozygous diploid null mutants have a random budding pattern; null mutant displays decreased resistance to alkaline pH, desiccation, UV, heat shock, oxidative stress but displays increased resistance to zinc deficiency; null has a reduced replicative lifespan, and is unable to undergo pseudohyphal growth; heterozygous null is haploinsufficient and has elevated chromosomal instability; overexpression results in a decreased growth rate

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources