Reference: Hernandez-Verdun D (2005) Nucleolus in the spotlight. Cell Cycle 4(1):106-8

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Abstract


The recent contributions on chromatid segregation at the metaphase/anaphase transition demonstrate two distinct pathways in budding yeast. While segregation of most of the genome is a direct consequence of cohesin cleavage by separase, rDNA segregation requires a novel pathway involving Cdc14 phosphatase activation. This activation induces targeting of condensin to rDNA which in association with Aurora B kinase modulates rDNA compaction during anaphase. The resolution of rDNA sequences occurs after this step.

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Journal Article | Review
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Hernandez-Verdun D
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