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MRX double-strand break repair complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Endo- and exonuclease complex that plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis via non-homologous end joining and homologous recombination.. The complex possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. Mre11 and Rad50 form an ATP-regulated nuclease that senses DSBs and tethers DNA via long Rad50 coiled-coil domains. Required for the formation of the DSB catalysed by the transesterase SPO11 (P23179) protein and subsequently removes covalently attached Spo11 from the 5' extremity of the breaks through its nuclease activity, to allow further break resection. The MRX complex also plays a role during meiosis in bridging DNA molecules together and in sensing SPO11 DSB and activating the DNA damage checkpoint. Clips double-stranded DNA in the vicinity of protein-blocked DNA ends.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ATP hydrolysis activity, DNA binding, hydrolase activity, nuclease activity, DNA damage response, DNA metabolic process, DNA repair, chromosome organization, response to stress, nucleus, organelle

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Cellular Component

Manually curated GO annotations reflect our best understanding of the basic cellular component for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.