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Ribosome quality control complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
A 60S-ribosomal subunit-associated complex involved in ubiquitin proteasome mediated degradation of polypeptides whose translation is stalled on the ribosome. The abnormal stalled ribosome is recognized and ubiquitinated at one or more specific residues by the E3 ubiquitin ligase HEL2 (Q05580) . Ribosome ubiquitination induces subunit dissociation by the RQT complex (CPX-6643). Dissociation of the 40S subunits allows binding of 60S ribosome-nascent chains to RQC2, which recruits the LTN1 E3 ubiquitin ligase. LTN1 ubiquitinates the nascent polypeptide chains, targeting them for degradation. RQC2 attaches C-terminal alanyl/threonyl sequences to stalled polypeptides. The ATPase CDC48 and cofactors UFD1 and NPL4 unfold ubiquitinated polypeptides, then extracts the peptidyl-tRNA from the 60S, thereby recruiting it to the 26S proteasome for degradation.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

acyltransferase activity, transferase activity, biosynthetic process, catabolic process, proteolysis involved in protein catabolic process, translational elongation

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.