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HOPS tethering complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Multisubunit tethering complex involved in endo-lysosomal vesicle trafficking and lysosome biogenesis by cross-linking two membranes, and facilitating the formation of a SNARE complex during fusion. Required for the delivery of vacuolar proteins and homotypic fusion of vacuoles and controls the clearance of late endosomes and autophagosomes during heterophagy and autophagy through promoting fusion of these vesicles with the vacuole Controls homotypic vacuole-vacuole fusion by regulating vesicle docking to the vacuole through its interaction with soluble SNAREs (CPX-1887), the GTP-bound form of the Rab protein YPT7 (P32939) and phosphoinositides. HOPS indirectly facilitates trans-SNARE complex formation by tethering membranes then protects newly formed trans-SNARE complexes from disassembly by SEC17/SEC18 (P32602/P18759). Reduces the levels of noncanonical trans-SNARE complexes formed during fusion, and further reduces the capacity of these mismatched complexes to undergo fusion. HOPS function is regulated through phosphorylation of its VPS41 subunit by YCK3 which lowers its affinity for vacuolar lipids.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

organelle fusion, vacuole organization