Primary Literature
TEXT HERE
- Marks SA, et al. (2024) Evidence that DNA polymerase δ proofreads errors made by DNA polymerase α across the Saccharomyces cerevisiae nuclear genome. DNA Repair (Amst) 143:103768 PMID: 39332392
- Mayle R, et al. (2024) DNA polymerase zeta has robust reverse transcriptase activity relative to other cellular DNA polymerases. J Biol Chem 107918. PMID: 39454951
- Reusswig KU, et al. (2022) Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions. Nat Commun 13(1):7014 PMID: 36400763
- Salay LE, et al. (2022) Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase. Biochemistry 61(11) PMID: 35617695
- Kassube SA and Thomä NH (2020) Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Nat Struct Mol Biol 27(8):735-742 PMID: 32632277
- Lewis JS, et al. (2020) Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication. Mol Cell 77(1):17-25.e5 PMID: 31704183
- Liu L, et al. (2020) Characterization of the dimeric CMG/pre-initiation complex and its transition into DNA replication forks. Cell Mol Life Sci 77(15):3041-3058 PMID: 31728581
- Porcella SY, et al. (2020) Separable, Ctf4-mediated recruitment of DNA Polymerase α for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation. PLoS Genet 16(5):e1008755 PMID: 32379761
- Yuan Z, et al. (2019) Ctf4 organizes sister replisomes and Pol α into a replication factory. Elife 8 PMID: 31589141
- Aria V and Yeeles JTP (2018) Mechanism of Bidirectional Leading-Strand Synthesis Establishment at Eukaryotic DNA Replication Origins. Mol Cell 73(2):199-211.e10 PMID: 30451148
- O'Brien E, et al. (2018) Yeast require redox switching in DNA primase. Proc Natl Acad Sci U S A 115(52):13186-13191 PMID: 30541886
- Bai L, et al. (2017) Architecture of the Saccharomyces cerevisiae Replisome. Adv Exp Med Biol 1042:207-228 PMID: 29357060
- Kilkenny ML, et al. (2017) The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box. Open Biol 7(11) PMID: 29167311
- Perez-Arnaiz P, et al. (2017) An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7. Nucleic Acids Res 45(12):7261-7275 PMID: 28510759
- O'Donnell M and Li H (2016) The Eukaryotic Replisome Goes Under the Microscope. Curr Biol 26(6):R247-56 PMID: 27003891
- Ramachandran A, et al. (2016) The Yeast Mitochondrial RNA Polymerase and Transcription Factor Complex Catalyzes Efficient Priming of DNA Synthesis on Single-stranded DNA. J Biol Chem 291(32):16828-39 PMID: 27311715
- Rice C and Skordalakes E (2016) Structure and function of the telomeric CST complex. Comput Struct Biotechnol J 14:161-7 PMID: 27239262
- Dubarry M, et al. (2015) Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae. G3 (Bethesda) 5(10):2187-97 PMID: 26297725
- Liu L and Huang M (2015) Essential role of the iron-sulfur cluster binding domain of the primase regulatory subunit Pri2 in DNA replication initiation. Protein Cell 6(3):194-210 PMID: 25645023
- Stuckey R, et al. (2015) Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system. Proc Natl Acad Sci U S A 112(18):5779-84 PMID: 25902524
- Sun J, et al. (2015) The architecture of a eukaryotic replisome. Nat Struct Mol Biol 22(12):976-82 PMID: 26524492
- Suwa Y, et al. (2015) Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit. J Biol Chem 290(23):14328-37 PMID: 25847248
- Doublié S and Zahn KE (2014) Structural insights into eukaryotic DNA replication. Front Microbiol 5:444 PMID: 25202305
- Langston LD, et al. (2014) CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication. Proc Natl Acad Sci U S A 111(43):15390-5 PMID: 25313033
- Vaithiyalingam S, et al. (2014) Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase. J Mol Biol 426(3):558-69 PMID: 24239947
- Perera RL, et al. (2013) Mechanism for priming DNA synthesis by yeast DNA polymerase α. Elife 2:e00482 PMID: 23599895
- Aves SJ, et al. (2012) Evolutionary diversification of eukaryotic DNA replication machinery. Subcell Biochem 62:19-35 PMID: 22918578
- Kilkenny ML, et al. (2012) A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome. J Biol Chem 287(28):23740-7 PMID: 22593576
- Suyari O, et al. (2012) Differential requirement for the N-terminal catalytic domain of the DNA polymerase ε p255 subunit in the mitotic cell cycle and the endocycle. Gene 495(2):104-14 PMID: 22245183
- Núñez-RamÃrez R, et al. (2011) Flexible tethering of primase and DNA Pol α in the eukaryotic primosome. Nucleic Acids Res 39(18):8187-99 PMID: 21715379
- Zheng L and Shen B (2011) Okazaki fragment maturation: nucleases take centre stage. J Mol Cell Biol 3(1):23-30 PMID: 21278448
- MacNeill SA (2010) Structure and function of the GINS complex, a key component of the eukaryotic replisome. Biochem J 425(3):489-500 PMID: 20070258
- Sauguet L, et al. (2010) Shared active site architecture between the large subunit of eukaryotic primase and DNA photolyase. PLoS One 5(4):e10083 PMID: 20404922
- Tanaka H, et al. (2009) Ctf4 coordinates the progression of helicase and DNA polymerase alpha. Genes Cells 14(7):807-20 PMID: 19496828
- Kim JM, et al. (2008) A copula method for modeling directional dependence of genes. BMC Bioinformatics 9:225 PMID: 18447957
- Klinge S, et al. (2007) An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Nat Struct Mol Biol 14(9):875-7 PMID: 17704817
- Lydeard JR, et al. (2007) Break-induced replication and telomerase-independent telomere maintenance require Pol32. Nature 448(7155):820-3 PMID: 17671506
- Das-Bradoo S, et al. (2006) Interaction between PCNA and diubiquitinated Mcm10 is essential for cell growth in budding yeast. Mol Cell Biol 26(13):4806-17 PMID: 16782870
- Petreaca RC, et al. (2006) Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p. Nat Cell Biol 8(7):748-55 PMID: 16767082
- Ricke RM and Bielinsky AK (2006) A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast. J Biol Chem 281(27):18414-25 PMID: 16675460
- Nedelcheva MN, et al. (2005) Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex. J Mol Biol 347(3):509-21 PMID: 15755447
- Early A, et al. (2004) Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage. Philos Trans R Soc Lond B Biol Sci 359(1441):31-8 PMID: 15065654
- Fien K, et al. (2004) Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p. J Biol Chem 279(16):16144-53 PMID: 14766746
- Grossi S, et al. (2004) Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes Dev 18(9):992-1006 PMID: 15132993
- Sundin BA, et al. (2004) Localization of proteins that are coordinately expressed with Cln2 during the cell cycle. Yeast 21(9):793-800 PMID: 15282802
- Wang X, et al. (2004) Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae. Mol Cell Biol 24(16):6891-9 PMID: 15282291
- Callahan JL, et al. (2003) Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. Mol Cell Biol 23(21):7849-60 PMID: 14560028
- Lottersberger F, et al. (2003) Functions of Saccharomyces cerevisiae 14-3-3 proteins in response to DNA damage and to DNA replication stress. Genetics 165(4) PMID: 14704161
- Muzi-Falconi M, et al. (2003) The DNA polymerase alpha-primase complex: multiple functions and interactions. ScientificWorldJournal 3:21-33 PMID: 12806117
- Pollok S, et al. (2003) Regulation of eukaryotic DNA replication at the initiation step. Biochem Soc Trans 31(Pt 1):266-9 PMID: 12546699
- Diaz RL, et al. (2002) Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Mol Cell Biol 22(4):1106-15 PMID: 11809802
- Srivastava VK and Busbee DL (2002) Replicative enzymes and ageing: importance of DNA polymerase alpha function to the events of cellular ageing. Ageing Res Rev 1(3):443-63 PMID: 12067597
- Augustin MA, et al. (2001) Crystal structure of a DNA-dependent RNA polymerase (DNA primase). Nat Struct Biol 8(1):57-61 PMID: 11135672
- Bryant JA, et al. (2001) Origins and complexes: the initiation of DNA replication. J Exp Bot 52(355):193-202 PMID: 11283163
- Davis L, et al. (2001) The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks. Genetics 157(3):1179-89 PMID: 11238403
- Griffiths DJ, et al. (2001) Role of fission yeast primase catalytic subunit in the replication checkpoint. Mol Biol Cell 12(1):115-28 PMID: 11160827
- Ireland MJ, et al. (2000) The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeast. Genetics 155(4):1657-65 PMID: 10924464
- Leipe DD, et al. (2000) The bacterial replicative helicase DnaB evolved from a RecA duplication. Genome Res 10(1):5-16 PMID: 10645945
- Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 PMID: 10733584
- Smith J, et al. (2000) Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance. Biochimie 82(1):71-8 PMID: 10717390
- Diede SJ and Gottschling DE (1999) Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta. Cell 99(7):723-33 PMID: 10619426
- Holmes AM and Haber JE (1999) Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases. Cell 96(3):415-24 PMID: 10025407
- Kamimura YI, et al. (1999) DNA helicase III of Saccharomyces cerevisiae, encoded by YER176w (HEL1), highly unwinds covalently closed, circular DNA in the presence of a DNA topoisomerase and yRF-A. J Biochem 125(2):236-44 PMID: 9990119
- Pajer P, et al. (1999) The "small" polydisperse cytoplasmic extrachromosomal DNA of chicken leukaemic myeloblasts and the avian myeloblastosis virus core-bound DNA seem to descend from origin regions of chromosomal DNA replication. Acta Virol 43(1):5-18 PMID: 10672338
- Pellicioli A, et al. (1999) Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J 18(22):6561-72 PMID: 10562568
- Weinreich M and Stillman B (1999) Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J 18(19):5334-46 PMID: 10508166
- Wittmeyer J, et al. (1999) Spt16 and Pob3 of Saccharomyces cerevisiae form an essential, abundant heterodimer that is nuclear, chromatin-associated, and copurifies with DNA polymerase alpha. Biochemistry 38(28):8961-71 PMID: 10413469
- Braguglia D, et al. (1998) Semi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template. J Mol Biol 281(4):631-49 PMID: 9710536
- Desdouets C, et al. (1998) Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha. EMBO J 17(14):4139-46 PMID: 9670028
- Tanaka T and Nasmyth K (1998) Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases. EMBO J 17(17):5182-91 PMID: 9724654
- Longhese MP, et al. (1997) The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. EMBO J 16(17):5216-26 PMID: 9311982
- Marini F, et al. (1997) A role for DNA primase in coupling DNA replication to DNA damage response. EMBO J 16(3):639-50 PMID: 9034345
- Zhu FX, et al. (1997) Purification and characterization of the DNA polymerase alpha associated exonuclease: the RTH1 gene product. Biochemistry 36(20):5947-54 PMID: 9166764
- Ferrari M, et al. (1996) Phosphorylation of the DNA polymerase alpha-primase B subunit is dependent on its association with the p180 polypeptide. J Biol Chem 271(15):8661-6 PMID: 8621497
- Foiani M, et al. (1996) A meiosis-specific protein kinase, Ime2, is required for the correct timing of DNA replication and for spore formation in yeast meiosis. Mol Gen Genet 253(3):278-88 PMID: 9003314
- Longhese MP, et al. (1996) Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase. Mol Cell Biol 16(7):3235-44 PMID: 8668138
- Foiani M, et al. (1995) Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase alpha-primase B subunit. Mol Cell Biol 15(2):883-91 PMID: 7823954
- Foiani M, et al. (1994) The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol Cell Biol 14(2):923-33 PMID: 8289832
- Longhese MP, et al. (1994) Replication factor A is required in vivo for DNA replication, repair, and recombination. Mol Cell Biol 14(12):7884-90 PMID: 7969128
- Skala J, et al. (1994) The sequence of an 8.8 kb segment on the left arm of chromosome II from Saccharomyces cerevisiae reveals four new open reading frames including homologs of animal DNA polymerase alpha-primases and bacterial GTP cyclohydrolase II. Yeast 10 Suppl A:S13-24 PMID: 8091857
- Biswas EE, et al. (1993) Purification and characterization of a yeast DNA polymerase alpha complex with associated primase, 5'-->3' exonuclease, and DNA-dependent ATPase activities. Biochemistry 32(12):3013-9 PMID: 7681325
- Longhese MP, et al. (1993) Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex. Genetics 133(2):183-91 PMID: 8436268
- Melendy T and Stillman B (1993) An interaction between replication protein A and SV40 T antigen appears essential for primosome assembly during SV40 DNA replication. J Biol Chem 268(5):3389-95 PMID: 8381428
- Miyazawa H, et al. (1993) Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle. J Biol Chem 268(11):8111-22 PMID: 8463324
- Santocanale C, et al. (1993) The isolated 48,000-dalton subunit of yeast DNA primase is sufficient for RNA primer synthesis. J Biol Chem 268(2):1343-8 PMID: 7678254
- Santocanale C, et al. (1992) Overproduction and functional analysis of DNA primase subunits from yeast and mouse. Gene 113(2):199-205 PMID: 1572541
- Brooke RG and Dumas LB (1991) Reconstitution of the Saccharomyces cerevisiae DNA primase-DNA polymerase protein complex in vitro. The 86-kDa subunit facilitates but is not required for complex formation. J Biol Chem 266(16):10093-8 PMID: 2037567
- Brooke RG, et al. (1991) Purification and characterization of the 180- and 86-kilodalton subunits of the Saccharomyces cerevisiae DNA primase-DNA polymerase protein complex. The 180-kilodalton subunit has both DNA polymerase and 3'----5'-exonuclease activities. J Biol Chem 266(5):3005-15 PMID: 1704371
- Erdile LF, et al. (1991) Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication. J Biol Chem 266(18):12090-8 PMID: 2050703
- Francesconi S, et al. (1991) Mutations in conserved yeast DNA primase domains impair DNA replication in vivo. Proc Natl Acad Sci U S A 88(9):3877-81 PMID: 2023935
- Jeansonne NE, et al. (1991) A 48-kDa, S-antigen-like phosphoprotein in yeast DNA-replicative complex preparations. J Biol Chem 266(22):14675-80 PMID: 1860866
- Lee SH, et al. (1991) Synthesis of DNA by DNA polymerase epsilon in vitro. J Biol Chem 266(33):22707-17 PMID: 1682323
- Johnston LH, et al. (1990) Expression of the yeast DNA primase gene, PRI1, is regulated within the mitotic cell cycle and in meiosis. Mol Gen Genet 221(1):44-8 PMID: 2183009
- Brooks M and Dumas LB (1989) DNA primase isolated from the yeast DNA primase-DNA polymerase complex. Immunoaffinity purification and analysis of RNA primer synthesis. J Biol Chem 264(6):3602-10 PMID: 2464600
- Budd ME, et al. (1989) Purification of DNA polymerase II, a distinct DNA polymerase, from Saccharomyces cerevisiae. J Biol Chem 264(11):6557-65 PMID: 2649504
- Foiani M, et al. (1989) Affinity labeling of the active center and ribonucleoside triphosphate binding site of yeast DNA primase. J Biol Chem 264(4):2189-94 PMID: 2644256
- Foiani M, et al. (1989) A single essential gene, PRI2, encodes the large subunit of DNA primase in Saccharomyces cerevisiae. Mol Cell Biol 9(7):3081-7 PMID: 2528682
- Kunkel TA, et al. (1989) Fidelity of DNA polymerase I and the DNA polymerase I-DNA primase complex from Saccharomyces cerevisiae. Mol Cell Biol 9(10):4447-58 PMID: 2555694
- Bauer GA, et al. (1988) DNA polymerase III from Saccharomyces cerevisiae. I. Purification and characterization. J Biol Chem 263(2):917-24 PMID: 3275661
- Lucchini G, et al. (1988) Genetic mapping of the Saccharomyces cerevisiae DNA polymerase I gene and characterization of a pol1 temperature-sensitive mutant altered in DNA primase-polymerase complex stability. Mol Gen Genet 212(3):459-65 PMID: 3047550
- Pizzagalli A, et al. (1988) DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases. Proc Natl Acad Sci U S A 85(11):3772-6 PMID: 3287376
- Plevani P, et al. (1988) The yeast DNA polymerase-primase complex: genes and proteins. Biochim Biophys Acta 951(2-3):268-73 PMID: 3061469
- Ticho BS and Getz GS (1988) The characterization of yeast mitochondrial RNA polymerase. A monomer of 150,000 daltons with a transcription factor of 70,000 daltons. J Biol Chem 263(21):10096-103 PMID: 3292522
- Lucchini G, et al. (1987) Yeast DNA polymerase--DNA primase complex; cloning of PRI 1, a single essential gene related to DNA primase activity. EMBO J 6(3):737-42 PMID: 3034609
- Plevani P, et al. (1987) The nucleotide sequence of the PRI1 gene related to DNA primase in Saccharomyces cerevisiae. Nucleic Acids Res 15(19):7975-89 PMID: 3313275
- Singh H, et al. (1986) Yeast DNA primase and DNA polymerase activities. An analysis of RNA priming and its coupling to DNA synthesis. J Biol Chem 261(18):8564-9 PMID: 2424899
- Jazwinski SM and Edelman GM (1985) A DNA primase from yeast. Purification and partial characterization. J Biol Chem 260(8):4995-5002 PMID: 3988742
- Plevani P, et al. (1985) Polypeptide structure of DNA primase from a yeast DNA polymerase-primase complex. J Biol Chem 260(11):7102-7 PMID: 3888995
- Wilson FE and Sugino A (1985) Purification of a DNA primase activity from the yeast Saccharomyces cerevisiae. Primase can be separated from DNA polymerase I. J Biol Chem 260(13):8173-81 PMID: 3159727
- Jazwinski SM and Edelman GM (1984) Evidence for participation of a multiprotein complex in yeast DNA replication in vitro. J Biol Chem 259(11):6852-7 PMID: 6373767
- Plevani P, et al. (1984) DNA polymerase I and DNA primase complex in yeast. J Biol Chem 259(12):7532-9 PMID: 6376490
- Singh H and Dumas LB (1984) A DNA primase that copurifies with the major DNA polymerase from the yeast Saccharomyces cerevisiae. J Biol Chem 259(12):7936-40 PMID: 6376495