ARG82 / YDR173C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant is sterile and auxotrophic for ornithine, arginine and myo-inositol; null mutant is heat sensitive, has a decreased growth rate on rich media, is unable to grow anaerobically and displays decreased competitive fitness on various media; null mutant is unable to utilize ornithine and has decreased ability to utilize ammonia as a nitrogen source; null mutant displays decreased autophagy, mitophagy, and has abnormal mitochondrial morphology; null mutant has decreased stress resistance; null mutant has altered inositol phosphate profiles; homozygous diploid null mutant has a G1 phase cell cycle delay, a strong sporulation defect, decreased glycogen accumulation and reduced desiccation resistance; heterozygous null mutant is haploproficient; overexpression results in a impaired mRNA export from the nucleus and enhanced invasive growth

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources